AnaSpec Introduces Fluorescent Endothelin GO Peptides
Summary
Press Release Pricing | News by Category | News by Country | News by US Region | Recent News | PR.com News on Your Site Press Releases AnaSpec, EGT Group Press Release Receive press releases from AnaSpec, EGT Group: By Email RSS Feeds: AnaSpec Introduces Fluorescent Endothelin GO Peptides San Jose, CA, November 13, 2010 --( Endothelins (ET) are highly potent vasoconstrictor proteins distributed throughout all areas of the body, and are implicated in a number of conditions and diseases.1 Members of the Endothelin family of peptides consist of Pre-pro-endothelin-1, a biologically inactive precursor form cleaved by furin covertase to produce Big Endothelin-1 (Big ET-1), which is cleaved again by endothelin converting enzyme (ECE) between Trp-21 and Val-22 to yield the active ET-1 (1-21).2 Alternatively, pulmonary chymase is also capable of generating ET-1 (1-31) by cleaving the Tyr31–Gly32 bond of big ET-1.2, 3 Isoforms include ET-2, ET-3, and ET-4.2 All have two disulfide bonds that hold them in a conical spiral shape.2 In addition to their vasoconstrictive properties, endothelins have inotropic and mitogenic properties.2 They influence salt and water balance, affect intracellular Ca2+ concentrations and signal transduction cascades, contract non-vascular smooth muscle, alter central and peripheral sympathetic activity, and stimulate the renin-angiotensin-aldosterone system.2-5 ETs are normally kept at stable levels in healthy individuals, but can become overexpressed, leading to high blood pressure, kidney disease, and numerous cardiovascular diseases such as pulmonary hypertension, cardiac hypertrophy, myocardial infarction, heart failure, and cerebral vasospasm.1, 2 ET disregulation is also a key component of tumorigenesis in several types of cancer.6 Fluorescently labeled endothelins have various applications in ET-related disease research.AnaSpec recently joined forces with Eurogentec to provide an even broader spectrum of products and services to serve the worldwide life science community.Eurogentec provides a wide range of expertize in small- and large-scale DNA, RNA, PCR and qPCR kits, peptide synthesis and antibody supply for research applications.With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and antibodies.AnaSpec recently joined forces with Eurogentec to provide an even broader spectrum of products and services to serve the worldwide life science community.For more information visit www.anaspec.comAbout EurogentecEurogentec is a leading global supplier of innovative reagents, kits, specialty products and custom services to scientists in the life science, biotechnology, pharmaceutical and diagnostic markets.Eurogentec provides a wide range of expertize in small- and large-scale DNA, RNA, PCR and qPCR kits, peptide synthesis and antibody supply for research applications.