Sugary drink consumption and risk of cancer: results from NutriNet-Santé prospective cohort
Summary
Thus, the aim of this study is to investigate the relations between the consumptions of sugary drinks and artificially sweetened beverages and the risk of first cancer in a large prospective cohort with detailed and up to date dietary intake assessment. We applied a bootstrap approach to the estimation of usual dietary intakes by variance reduction as sensitivity analysis, followed by testing Fine and Gray models to account for extra variation. We assessed and tested the potential nonlinear effects of continuous exposure variables by using restricted cubic spline transformations in multivariable models of competing endpoints (appendix 7). Based on these databases, we could complete information regarding health events and deaths, thereby limiting any potential bias owing to participants with cancer who might not report their disease to the study investigators. If these results are replicated in further large-scale prospective studies and supported by mechanistic experimental data, and given the large consumption of sugary drinks in Western countries, these beverages would represent a modifiable risk factor for cancer prevention, beyond their well established impact on cardiometabolic health.
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