Engineered CAR T cells successfully target bladder cancer in mice

▤ Summary

Researchers developed engineered CAR T cells that target the MUC16 protein on bladder cancer cells. They tested the approach in mouse models and found that direct catheter delivery into the bladder controlled tumor growth better than intravenous delivery. The localized delivery also reduced the risk of off-target effects in other tissues. The findings point to a potential bladder-sparing treatment strategy for patients with high-risk or treatment-resistant disease.

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