Cincera Therapeutics
Summary
Altered levels (quantity) and abundance (quality) of key bioactive lipids can induce tissue inflammation. Lipotoxicity contributes to the high prevalence of conditions such as Metabolic Syndrome or Type 2 diabetes and more serious co-morbidities such as CKD (chronic kidney disease) and non-alcoholic fatty liver disease (NAFLD). Our novel agents have shown potent cell mediated anti-inflammatory/anti-fibrotic properties and display a broad mechanism of action founded in the modulation of the relative abundance of key bioactive lipids (i.e. quality), rather than directly affecting total lipid levels (i.e. quantity). This orthogonal approach supports single agent efficacy but is also highly compatible for combination therapies with incumbent or leading metabolic disease therapies targeting NASH and associated indications. Cincera has potent and selective compounds currently under optimisation and pre-clinical efficacy assessment in key disease models.