Personalizing Pharmacotherapy Through Individualized Drug Dosing Calculators
Summary
While general pharmacotherapy guidances apply to healthy individuals, special populations such as pediatrics, critically ill or those with chronic kidney disease require additional considerations. For those populations, standard pharmacotherapy regimes need to be modified taking into account factors such as alterations to rates of drug absorption, distribution, metabolism and excretion. In recent years, multiple drug dosing calculators have come to market to enable such specialized pharmacotherapy. However, the algorithms in most of those calculators are opaque to the end user and provide little opportunity for further customization. We’ll also touch on several other examples of how data-driven solutions can improve patient outcomes & healthcare efficiency, and run through several use cases developed through a collaboration between KNIME and Virginia Commonwealth University (VCU).