AnaSpec Introduces α & β -Synuclein Recombinant Proteins
Summary
Eurogentec provides a wide range of expertize in small- and large-scale DNA, RNA, PCR and qPCR kits, peptide synthesis and antibody supply for research applications.In vitro incubation in the presence of salt (i.e. 0.1M NaCl) with agitation causes a-Synuclein to form fibrils.2-6 a-Synuclein, labeled with AnaSpec’s proprietary green dye, HiLyte Fluor™ 488 (Ex/Em=503/525 nm) is also available.b-SynucleinN-terminal of β-synuclein is highly homologous to α-, γ-synucleins and consists of degenerative “KTKEGV” repeats.7-10 Similar to α-synuclein, beta-synuclein is found primarily in the brain; however, it does not associate with Lewy bodies in Parkinson disease like α-synuclein.7-10 Beta-synuclein was found to inhibit production of phosphatidic acid by the phospholipase D2 transmembrane protein in vitro.7 In addition, β-synuclein was detected in many breast and ovarian tumors.7 Recent investigations demonstrated that β-synuclein can induce mild experimental autoimmune encephalomyelitis (EAE) in Lewis rats.8ReferencesGeorge, JM.Genome Biol 3, 3002.1 (2001).Bruening, W. et al. Am Cancer Soc 88, 2154 (2000).Kela-Madar, N. et al. J Neuroimmunol 208, 19 (2009).About AnaSpecAnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions.With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and antibodies.AnaSpec recently joined forces with Eurogentec to provide an even broader spectrum of products and services to serve the worldwide life science community.For more information visit www.anaspec.comAbout EurogentecEurogentec is a leading global supplier of innovative reagents, kits, specialty products and custom services to scientists in the life science, biotechnology, pharmaceutical and diagnostic markets.Eurogentec provides a wide range of expertize in small- and large-scale DNA, RNA, PCR and qPCR kits, peptide synthesis and antibody supply for research applications.