PiscoMeds Journal AMOR Releases a Study on Intestinal Metaplasia
Summary
More than a decade after the brave doctor infected himself and remedied his self-induced illness with antibiotics, H. pylori remains as one of the most prevalent causes of gastric cancer and has attracted the interest of researchers across multi-disciplines from all over the world.One such researcher, Dr. Sergii Vernygorodskyi from the Department of Pathological Anatomy at Vinnitsa National Pirogov Memorial Medical University, Ukraine, has studied the role of the infamous corkscrew-shaped “gut bug” in the formation of intestinal metaplasia of the gastric mucosa (mucous membrane layer of the stomach).In an exclusive interview with AMOR Media team, Dr. Vernygorodskyi explained, “I chose to focus on this particular topic for my research because the metaplasia and dysplasia of the stomach mucosa in pre-tumor and neoplastic processes and their relationships with H. pylori remain uninvestigated.” He concluded that more studies should be done to “clarify the significance of DNA methylation alterations during precancerous processes and gastric carcinogenesis and to understand the genetic basis of precancerous lesions and their relationships with H. Pylori.” Read more of Dr. Sergii Vernygorodskyi’s research on AMOR website at www.advmodoncolres.com.As he was unable conduct his study on mice (H. pylori only affects primates), he ran the experiment on the only human patient who would consent to such a procedure: himself.More than a decade after the brave doctor infected himself and remedied his self-induced illness with antibiotics, H. pylori remains as one of the most prevalent causes of gastric cancer and has attracted the interest of researchers across multi-disciplines from all over the world.One such researcher, Dr. Sergii Vernygorodskyi from the Department of Pathological Anatomy at Vinnitsa National Pirogov Memorial Medical University, Ukraine, has studied the role of the infamous corkscrew-shaped “gut bug” in the formation of intestinal metaplasia of the gastric mucosa (mucous membrane layer of the stomach).Persistent infection of the bacteria H. pylori is an etiological factor of intestinal metaplasia and leads to the formation of gastrointestinal phenotype of intestinal metaplasia, explained Dr. Vernygorodskyi in his paper which was published in the open-access peer reviewed journal Advances in Modern Oncology Research (AMOR).“[H. pylori] inhibits the expression of SOX2 in gastric epithelial cells, hence activating transcription factor CDX2 as a counterpart to MUC5AC gene inhibition and MUC2 gene induction,” elaborated Dr. Vernygorodskyi.“Hence, differentiated approach based on the usage of molecular biological markers for intestinal metaplasia is not only of scientific interest but is also a fundamental basis for the development of methodical approaches in the prognosis and treatment of patients with intestinal metaplasia of gastric mucosa,” the researcher opined.In an exclusive interview with AMOR Media team, Dr. Vernygorodskyi explained, “I chose to focus on this particular topic for my research because the metaplasia and dysplasia of the stomach mucosa in pre-tumor and neoplastic processes and their relationships with H. pylori remain uninvestigated.”He concluded that more studies should be done to “clarify the significance of DNA methylation alterations during precancerous processes and gastric carcinogenesis and to understand the genetic basis of precancerous lesions and their relationships with H. Pylori.”Read more of Dr. Sergii Vernygorodskyi’s research on AMOR website at www.advmodoncolres.com.