Making the invisible visible

▤ Summary

Researchers at Biohub and UC Berkeley have developed laser phase plate technology that sharply improves cryo-EM image contrast. The new microscope setup makes small proteins and structures inside intact cells easier to see, including targets linked to disease. The teams report successful results for both single-laser and dual-laser versions, with measurable gains in resolution and contrast. The work could accelerate structural biology research and open new workflows for imaging proteins in their native cellular environment.

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